Endocrine Abstracts

The adrenal glands serve as central organs of the endocrine system by producing steroid hormone essential for organismal homeostasis. Mechanisms ensuring proper adrenal homeostasis and function are therefore crucial for maintaining human life. ACTH, released by the pituitary corticotrope, is required for the differentiation of the inner part of the adrenal cortex (the zona fasciculata) and the resultant stimulation of cortisol production. Perturbation of ACTH signaling can lea...

The adrenal cortex synthesizes glucocorticoids that are essential for metabolic homeostasis and modulation of immune responsiveness. Glucocorticoid-producing cells, located in the zona fasciculata (zF), constitute the critical effector of the HPA axis that serves to mediate the mammalian stress response. Dysregulation of glucocorticoid function results in significant morbidity with complete deficiency being incompatible with life. While the zF is composed of heterogenous cell ...

Introduction: Prolactinomas are benign tumors usually well controlled with dopamine agonists; few progress on medical therapy through unclear molecular mechanisms. Although the SF3B1 mutation has been recently associated with aggressive prolactinomas, in most cases, no genetic mutations have been reported. We aimed to identify somatic genetic alterations associated with prolactinomas using a gene panel.Method and Results: Oncopanel, a massively ...